NWO – TTW – OTP | XLbone


Bridging the gap: aXelerated Large bone defect healing (XLbone)


Bone is the second most transplanted tissue worldwide. There is an urgent need for the development of a new generation of bone substitutes.

Tissue-engineered constructs, consisting of cells, biomaterials and bioactive molecules, can offer a promising alternative. With these, mimicry of the natural pathway for bone formation via a cartilage intermediate is feasible.

In this project, the mechanisms will be unraveled that underlie a novel bone regenerative strategy that is based on creating a scalable cartilage template. Also, the project will generate a proof of concept for the restoration of large bone defects of clinically relevant size.


  • Universitair Medisch Centrum Utrecht


  • Universitair Ziekenhuis Heidelberg


NWO TTW – Open Technology Program

(Website with) more information



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