Bridging the gap: aXelerated Large bone defect healing (XLbone)
Bone is the second most transplanted tissue worldwide. There is an urgent need for the development of a new generation of bone substitutes.
Tissue-engineered constructs, consisting of cells, biomaterials and bioactive molecules, can offer a promising alternative. With these, mimicry of the natural pathway for bone formation via a cartilage intermediate is feasible.
In this project, the mechanisms will be unraveled that underlie a novel bone regenerative strategy that is based on creating a scalable cartilage template. Also, the project will generate a proof of concept for the restoration of large bone defects of clinically relevant size.
- Universitair Medisch Centrum Utrecht
- Universitair Ziekenhuis Heidelberg
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